Tenosynovial Giant Cell Tumor

Tenosynovial Giant Cell Tumor, Case Report and Review

by David R. Lucas, MD

March 30, 2012.



www.archivesofpathology.org/doi/pdf/10.5858/arpa.2012-0165-CR

Trisomy 7 changes found in PVNS

Many forms of cancer are associated with damage to chromosome 7. In particular, changes in this chromosome have been identified in cancers of blood-forming tissue (leukemias) and cancers of immune system cells (lymphomas). A loss of part or all of one copy of chromosome 7 is common in myelodysplastic syndrome, which is a disease of the blood and bone marrow. People with this disorder have an increased risk of developing leukemia. 

More here

Research shows that PVNS is associated with Trisomy 7.

Research abstract here.

Trisomy 5 and Trisomy 7 Found in PVNS

Pigmented villonodular synovitis (PVNS) is a proliferative lesion of disputed genesis. Researchers previously reported trisomy 7 in short-term cultures of 1 PVNS and subsequently found another specimen of PVNS in which 9 of 26 (35 percent) metaphase cells demonstrated trisomy 7 when analyzed after 3-15 days of tissue culture. 



Read more here: Trisomy 5 and trisomy 7 are nonrand... [Genes Chromosomes Cancer. 1992] - PubMed - NCBI

Harvard Orthopaedic Journal: Articles

"In our opinion, arthroscopic and limited open techniques (4,20,28) provide inadequate exposure of the knee joint, particularly postero-laterally and in the region of the popliteus tendon. Furthermore, most reports of treatment of DPVNS have small numbers of patients, often collected over a number of years with more than one joint included. (1,2,8,8,12,16,18,22) To the best of our knowledge, no reports in the literature contain large numbers of patients with DPVNS of the knee, with adequate preoperative staging, and long-term clinical or MRI evaluation. (15,17,21)"

The article concludes:  "The results of our study suggest that complete synovectomy is the procedure of choice to decrease the risk of recurrence of DPVNS of the knee. Arthroscopic or limited open techniques or radiotherapy may reduce the amount of DPVNS tissue and associated symptoms in the short term, but will not eradicate the disease. In contrast, an extensile open surgical approach allows excellent visualization for removal of intra-and extra-articular DPVNS tissue with an acceptably low complication rate. We continue to use arthroscopy for pre- or post-operative diagnostic biopsies or treatment of early primary or residual disease following open synovectomy. Our current practice is to assess patients with MRI pre-operatively, three months post-operatively, and annually thereafter." 

Read the entire article here: Harvard Orthopaedic Journal: Articles

Note: I can't locate a date on this article, but the most recent citation at the end of the article is dated 1999, so this Harvard article is more recent than 1999.